Endocrine Abstracts

Objective: The main physiological function of the renin-angiotensin-aldosterone system (RAAS) is the regulation of water and salt homeostasis as well as arterial blood pressure. In addition, the RAAS is proposed to be involved in the pathophysiology of several diseases like hypertension, vascular remodelling, atherosclerosis, insulin resistance and type 2 diabetes mellitus. In a cohort study in north-east Germany, we investigated the association of plasma renin- (PRC) or plasm...

Objective: Although subclinical thyroid dysfunction is associated with cardiac endpoints such as endothelial dysfunction, left ventricular hypertrophy, thickened artery walls or atrial fibrillation, it is currently under debate whether subclinical hyper- or hypothyroidism as well as thyroid function within the reference range are associated with an increased risk of hypertension. So far no study investigated the association between thyroid function and blood pressure in childr...

Background: Osteocalcin (OC) is a bone-specific protein produced primarily by osteoblasts during bone formation. The OC concentration is used to assess fracture risk and monitor treatment of osteoporosis and other disorders of bone metabolism. To adequately interpret the OC concentration, it is necessary to calculate reference ranges from a healthy reference population, adapted to a specific laboratory method.Methods: We established a healthy reference p...